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December 1983

Effects of Elevated IOP on Blood Flow

Arch Ophthalmol. 1983;101(12):1948-1949. doi:10.1001/archopht.1983.01040020950028

To the Editor.  —Sossi and Anderson made some important observations in two January Archives articles (1983;101:94-97 and 98-101), and I would like to comment on them.

Angiotensin, arterial hypertension and optic nerve-head ischemia.  —In the first article, the authors showed that intravenous (IV) infusion of angiotensin led to ischemic damage to the axons in the optic nerve head, despite high perfusion pressure. Our studies on experimental renovascular malignant arterial hypertension in about 40 rhesus monkeys support their observations. We produced the hypertension by the Goldblatt procedure. In these animals, the renin-angiotensin-aldosterone system plays an important role in the production of malignant hypertension, and plasma renin activity and concentrations of angiotensin and aldosterone are raised. It is well known that angiotensin is a powerful vasoconstrictor. In our monkeys with malignant hypertension, signs of anterior ischemic optic neuropathy developed in the majority of the eyes, with a peak systolic BP reading of

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