To the Editor.
—We recently described the antibacterial effects of cyanoacrylate glue in the June Archives.1 In that article we reported that enbucrilate (butyl-2-cyanoacrylate; Histoacryl [West Germany], no comparable US product) exhibited bacteriostatic activity against gram-positive organisms but not against gram-negative organisms.Several inexpensive cyanoacrylates are now available from Japan. We tested the antimicrobial effect of ultra-quick-setting methyl cyanocarylate, ultra-quick-setting ethyl cyanoacrylate, quick-setting ethyl cyanoacrylate, and butyl cyanoacrylate.There was no substantial difference among any of these compounds with respect to gram-positive organisms; however, butyl cyanoacrylate showed bacteriostatic activity against Serratia marcescens, Pseudomonas aeruginosa, and Enterobacter aerogenes. We treated two patients with gram-negative ulcers with impending perforation with butyl cyanoacrylate without complications. These compounds may prove to be effective adjunctive treatment in corneal disease.
Eiferman RA, Snyder JW. Cyanoacrylate Glue. Arch Ophthalmol. 1984;102(2):192–194. doi:10.1001/archopht.1984.01040030146007