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February 1984

Respirator Retina

Author Affiliations

From the Department of Pathology and the Jules Stein Eye Institute, UCLA School of Medicine (Dr Foos) and the Department of Pathology and Cajal Laboratory of Neuropathology, University of Southern California School of Medicine, Los Angeles (Dr Rhodes).

Arch Ophthalmol. 1984;102(2):296-303. doi:10.1001/archopht.1984.01040030240034

• Retinas from 14 comatose patients, who had been sustained with a respirator for one or more days before death, had selective characteristic alterations (ie, autophagy, cell swelling, and coagulation necrosis) of inner nuclear layer in a patchy pattern in posterior fundus. Bipolar cells were most often affected, but amacrine and horizontal cells also were substantially damaged. Cells of Müller and vascular cells were largely spared. These lesions are ascribed to oligemia (ischemia) since the inner nuclear layer is a microscopic vascular watershed (boundary zone) between the choroidal and retinal circulations.

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