• One-gram doses of cefonicid sodium were given intravenously to patients prior to cataract surgery. Although serum levels were high, cefonicid levels in aqueous humor were low: mean peak concentrations of 0.25 and 0.27 mg/L were observed two and four hours after administration, respectively. The unusually high protein binding of cefonicid may explain these observations. The observed concentrations were not above the minimum inhibitory concentrations of cefonicid for those pathogens commonly involved in bacterial endophthalmitis.
Axelrod JL, Kochman RS. Cefonicid Concentrations in Human Aqueous Humor. Arch Ophthalmol. 1984;102(3):433–434. doi:10.1001/archopht.1984.01040030347035
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