[Skip to Navigation]
May 1984

Transport of Fluorescein in the Ocular Posterior Segment in Retinitis Pigmentosa

Author Affiliations

From the Ophthalmology Department, Eye and Ear Infirmary (Drs Mallick, Zeimer, Fishman, and Blair), and the Epidemiology-Biometry Program, School of Public Health (Dr Anderson), University of Illinois, Chicago.

Arch Ophthalmol. 1984;102(5):691-696. doi:10.1001/archopht.1984.01040030547013

• The function of the blood-retinal barrier was assessed by vitreous fluorophotometry in 12 patients with various genetic types of retinitis pigmentosa and in 11 normal subjects. The measurements were corrected to minimize the effect of artifacts. We evaluated the inward penetration of fluorescein sodium across the blood-retinal barrier and determined the outward permeability coefficient for fluorescein by interpreting the data with a pharmacokinetic computer model. Patients with retinitis pigmentosa had increased inward permeability and decreased outward permeability to fluorescein in comparison with values of normal subjects.