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May 1984

Chemical Preparation of the Eye in Ophthalmic Surgery: III. Effect of Povidone-Iodine on the Conjunctiva

Author Affiliations

From the Departments of Ophthalmology (Drs Apt, Isenberg, and Paez) and Pathology (Dr Yoshimori), Jules Stein Eye Institute and Harbor-UCLA Medical Center, UCLA School of Medicine.

Arch Ophthalmol. 1984;102(5):728-729. doi:10.1001/archopht.1984.01040030584025

• A half-strength povidone-iodine (Betadine) solution was used topically as part of the preoperative chemical preparation of the eye. Aerobic and anaerobic bacterial cultures of the conjunctiva were taken before and after the chemical preparation in 30 consecutive patients; the second eye served as a control. In the control eyes, no significant change in the number of colonies or species of bacteria was found. In the povidone-iodine-treated eyes, the numbers of colonies decreased 91% and the number of species decreased 50% (statistically significant). We therefore recommend that a halfstrength povidone-iodine solution be used as part of the chemical preparation of the eye for surgery.