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May 1984

Experimental Retinal Detachment: VI. The Permeability of the Blood-Retinal Barrier

Author Affiliations

From the Department of Ophthalmology, University of Minnesota, Minneapolis.

Arch Ophthalmol. 1984;102(5):747-751. doi:10.1001/archopht.1984.01040030595029

• Fluorophotometry was used to study the permeability of the blood-retinal barrier in six monkeys with stable rhegmatogenous retinal detachments. Fluorescein transport was inhibited by probenecid. The rate of fluorescein disappearance (KvVv) was determined following intravitreal injection. In a separate experiment the equilibrium vitreous-plasma concentration ratio (Cv/Cp) was determined following intraperitoneal administration. Expressed in equivalent volumes of vitreous, the rate of fluorescein diffusion across the blood-retinal barrier (K′vVvCv/ Cp) was 0.29 μL/min in control eyes and 0.73 μL/min in detached eyes. The rate of fluid movement across the blood-retinal barrier (K′vVv) [1 - (Cv/Cp)] was 2.89 μL/min in control eyes and 6.38 μL/min in detached eyes. Posterior movement of fluid contributes to retinal apposition under normal conditions and accounts for the rapid resolution of retinal detachment following closure of the retinal hole.