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May 1984

Experimental Ocular Herpetic Infections in Rabbits: Treatment With 9-([2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine

Author Affiliations

From the Departments of Microbiology (Dr Smith, Mss Hodges and Galloway, and Mr Kennell) and Ophthalmology (Dr Poirier), The University of Texas Health Science Center at San Antonio; and the Department of Chemistry, McGill University, Montreal (Dr Ogilvie and Mr Cheriyan).

Arch Ophthalmol. 1984;102(5):778-781. doi:10.1001/archopht.1984.01040030626036

• A new acyclic nucleoside, 9-([2hydroxy-1-(hydroxymethyl)ethoxy]methyl)guanine (BIOLF-62), was found to be efficacious in the treatment of experimental ocular herpes simplex virus infections in rabbits. Complete healing of herpetic lesions occurred in a majority of animals after six days of topical treatment, three times per day. No toxic effects were observed in uninfected, drug-treated eyes. The BIOLF-62 treatment blocked viral replication in infected eyes sufficiently to make recovery of virus from any of the drug-treated eyes impossible, whereas virus was recovered from all placebo-treated eyes.