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June 1984

Hematoporphyrin Photoradiation Therapy for Intraocular and Orbital Malignant Melanoma

Author Affiliations

From the Department of Ophthalmology, University of Iowa Hospitals and Clinics, Iowa City. Dr Dutton was a Heed Ophthalmic fellow, 1982-1983. He is now with the Department of Ophthalmology, Duke University Eye Center, Durham, NC.

Arch Ophthalmol. 1984;102(6):833-838. doi:10.1001/archopht.1984.01040030653011

• Photoradiation therapy (PRT) is a new technique that is currently under investigation for the treatment of a variety of solid malignant tumors. The technique involves systemic administration of hematoporphyrin derivative (HpD), a photosensitizing compound that is preferentially retained by malignant cells and photoactivation of the neoplasm with red light (630 nm) to achieve selective destruction of cancer cells. We used HpD PRT for seven patients with malignant melanoma of the uvea and conclude that initial results of HpD PRT for uveal malignant melanoma are encouraging and justify further investigation.

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