• We describe two patients (two eyes) with neovascular glaucoma following photoradiation therapy (PRT) for ciliary body and iris melanoma. Histopathologic examination in one eye eight months after treatment disclosed widespread tumor necrosis. The second patient with iris melanoma showed total clinical disappearance of the lesion and regression of iris neovascularization six months later. The cause of the neovascular glaucoma is uncertain. The marked tumor necrosis induced by PRT might have resulted in release of a vasoproliferative factor that, in turn, led to the development of rubeosis and neovascular glaucoma.
Lewis RA, Tse DT, Phelps CD, Weingeist TA. Neovascular Glaucoma After Photoradiation Therapy for Uveal Melanoma. Arch Ophthalmol. 1984;102(6):839–842. doi:10.1001/archopht.1984.01040030659012
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: