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June 1984

Clearance From the Anterior Chamber of RBCs From Human Diabetics

Author Affiliations

From the Departments of Ophthalmology (Drs Williams and Hatchell), Physiology (Dr Hatchell), and Nuclear Medicine (Dr Collier and Ms Knobel), Medical College of Wisconsin, Milwaukee, and the Research Service, Wood Veterans Administration Medical Center, Milwaukee (Dr Hatchell).

Arch Ophthalmol. 1984;102(6):930-931. doi:10.1001/archopht.1984.01040030750038

• Erythrocytes from diabetic patients manifest decreased deformability and increased adherence. These abnormal membrane properties may diminish the ability of erythrocytes (RBCs) from diabetics to undergo deformation in passage through the trabecular meshwork. Using sodium chromate Cr 51-labeled RBCs from type I diabetic patients with proliferative retinopathy and normal control subjects, we studied RBC clearance from the rabbit anterior chamber. The mean time for 50% clearance (T50) of RBCs from diabetics (76 hours) was significantly longer than that for RBCs from normal subjects (19.5 hours). In this model, RBCs from diabetics have a slower clearance from the anterior chamber than do RBCs from normal subjects.

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