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July 1984

Experimental Uveitis: Elicited by Peptidoglycan-Polysaccharide Complexes, Lipopolysaccharide, and Muramyl Dipeptide

Author Affiliations

From the Departments of Microbiology and Immunology (Dr Fox), Ophthalmology (Drs Hammer, Burch, and Burrish), and Pathology (Dr Lill), University of South Carolina School of Medicine, Columbia. Dr Burrish is now with the Department of Dermatology, University of California-San Francisco School of Medicine.

Arch Ophthalmol. 1984;102(7):1063-1067. doi:10.1001/archopht.1984.01040030857033

• Uveitis could be a reaction to bacterial debris disseminated to the eye from extraocular sites of infection. In this study, we relate the composition of several bacterial components to their inflammatory properties in the eye. Groups of rabbits were injected intravitreously with peptidoglycan-polysaccharide (PG-PS) complexes isolated from group A streptococci, Escherichia coli lipopolysaccharide (LPS), or synthetic muramyl dipeptide (MDP). The lipid A region of LPS and the glycan backbone of PG are chemical analogues; MDP is the minimal biologically active subunit of PG. All of these molecules elicited uveitis as observed both clinically and histologically. The MDP elicited an acute inflammation characterized by a heterophil and monocyte infiltrate that subsided within 16 days. The PG-PS and LPS elicited chronic inflammation characterized by mononuclear and lymphocyte infiltration and severe necrosis of the retina.