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July 1984

Effect of Lensectomy on the Movement of Tracers From Vitreous to Aqueous

Author Affiliations

From the Center for Vitreoretinal Research, The Wilmer Ophthalmological Institute, The Johns Hopkins University, Baltimore.

Arch Ophthalmol. 1984;102(7):1077-1078. doi:10.1001/archopht.1984.01040030871036

• To investigate the effect of extracapsular lensectomy with posterior capsulotomy, 20,000- and 70,000-dalton dextran was injected into the vitreous of rabbits. The concentration of the 20,000-dalton dextran in the aqueous of aphakic eyes was 14-fold greater than in phakic eyes 3.5 hours after injection of dextran into the vitreous. The aqueous concentration of the 70,000-dalton dextran was four times greater in aphakic eyes after 3.5 hours. The aqueous concentration of a 20,000-dalton dextran in phakic and aphakic eyes became equal between 15.5 and 22.0 hours after injection. Thus, extracapsular lensectomy with posterior capsulotomy increased the rate of movement of a single bolus of both 20,000- and 70,000-dalton dextran preparations from the vitreous to the anterior chamber.