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August 1984

Treatment of Glaucoma Using Minidrops of Clonidine

Author Affiliations

From the Departments of Ophthalmology (Drs Petursson and Cole) and Pharmacology (Dr Hanna), University of Arkansas for Medical Sciences, Little Rock.

Arch Ophthalmol. 1984;102(8):1180-1181. doi:10.1001/archopht.1984.01040030958024

• A single regular (70 μL) or mini (15 μL) eyedrop of 0% (placebo), 0.25%, and 0.50% strengths of clonidine hydrochloride was administered to 16 patients with open-angle glaucoma in a double-masked crossover study. Both the regular drops and minidrops of 0.25% and 0.50% concentrations of the drug substantially lowered the intraocular pressure over a five-hour period as compared with the placebo. Only the regular drops of 0.50% clonidine substantially lowered the systemic BP. These results indicate the value of using a smaller volume of clonidine drop as an ocular hypotensive agent to avoid systemic effects.

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