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October 1984

Hyperthermic Treatment of Intraocular Tumors

Author Affiliations

From the Medical Research Center, Brookhaven National Laboratory, Upton, NY (Drs Finger and Packer and Mr Svitra); the David Sarnoff Research Center, RCA Laboratories, Princeton, NJ (Mr Paglione); and the Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston (Drs Chess and Albert).

Arch Ophthalmol. 1984;102(10):1477-1481. doi:10.1001/archopht.1984.01040031197017

• A 5.8-gigahertz (GHz) ophthalmic microwave applicator was used to treat choroidal melanoma (Greene strain) in rabbits. High-frequency electromagnetic radiation provides a favorable dose distribution to induce local hyperthermia in the treatment of intraocular tumors. Heating of the neoplasm, while sparing normal ocular structures, is best accomplished by a transscleral approach. A hyperthermia plaque is placed on the sclera at the base of the intraocular tumor. Contact (resistive) heating and electromagnetic radiation (radiofrequency and microwave) are best suited to a plaque technique. The advantages of electromagnetic heat induction, as compared with contact heating, are twofold: the depth of hyperthermic penetration can be modulated by frequency selection, and the tissues with low water content (sclera) remain relatively unaffected by microwaves. The 5.8-GHz ophthalmic microwave applicator satisfies the requirements for local hyperthermic treatment of intraocular tumors.

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