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November 1984

Laser-Induced Primate Glaucoma: II. Histopathology

Author Affiliations

From the Eye Institute, Medical College of Wisconsin, Milwaukee (Dr Radius), and the Department of Ophthalmology, University of Minnesota, Minneapolis (Dr Pederson).

Arch Ophthalmol. 1984;102(11):1693-1698. doi:10.1001/archopht.1984.01040031377031

• A sustained, moderate pressure elevation was produced in 15 nonhuman primate eyes by application of laser energy to the trabecular meshwork. By light and electron microscopy, the trabecular beams were blunted, and scattered synechiae were present. Backward bowing of the lamina cribrosa, partial loss of the myelin sheath surrounding axonal segments just posterior to the lamina, and diffuse axonal loss involving the entire nerve cross section were noted. A quantitative analysis of this axonal loss revealed that eyes with moderate nerve head damage (cup-disc ratio, 0.6 to 0.8) had only 38% to 69% of the expected normal axonal count. The eyes with nearly total cupping (cup-disc ratio, 0.9 to 1.0) maintained between 10% and 36% of the normal axonal count. The disc changes in these experimental eyes are similar to those previously described in human eyes with glaucoma.

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