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December 1984

Carbonic Anhydrase Inhibitors Induce Elevations in Human Whole-Blood Zinc Levels

Author Affiliations

From the Department of Epidemiology, Harvard School of Public Health, Boston, and the Division of Epidemiology and Biostatistics, International Agency for Research on Cancer, Lyon, France (Dr Walker); and the Glaucoma Consultation Service and Howe Laboratory of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston (Drs Arrigg and Epstein and Ms Hertzmark).

Arch Ophthalmol. 1984;102(12):1785-1787. doi:10.1001/archopht.1984.01040031449020

• The use of carbonic anhydrase inhibitors (CAIs) was associated with mean increases in whole-blood zinc levels of 82 μg/dL and 70 μg/dL, respectively, in a cross-sectional survey and in a prospective study of patients with glaucoma. The time course of the increase suggests that CAIs induce reticulocyte synthesis of carbonic anhydrase.

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