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December 1984

Betaxolol and AcetazolamideCombined Ocular Hypotensive Effect

Arch Ophthalmol. 1984;102(12):1794-1795. doi:10.1001/archopht.1984.01040031458022

• To determine the combined ocular hypotensive effect of topical betaxolol hydrochloride and oral acetazolamide, we conducted a three-week clinical trial of the concurrent administration of the two drugs. One drop of betaxolol hydrochloride 0.5% every 12 hours effected a mean reduction in outflow pressure from base-line of 27.3%. When given topically to both eyes of a patient pretreated with oral acetazolamide (500 mg every 12 hours), betaxolol caused an additional mean outflow pressure decrease of 17.6%. Acetazolamide, 500 mg orally every 12 hours, produced a mean outflow pressure reduction from baseline of 42.5%. When added to the therapy regimen of a patient already receiving topical betaxolol, oral acetazolamide caused an additional mean outflow pressure decrease of 35.1%. Our study supports the clinical usefulness of concurrent administration of betaxolol and acetazolamide to lower intraocular pressure.