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December 1984

Prophylactic Topical Cyclosporine in Experimental Herpetic Stromal Keratitis

Author Affiliations

From the Eye Research Institute of Retina Foundation (Drs Boisjoly, Pavan-Langston, and Park); the Department of Ophthalmology, Harvard Medical School (Drs Boisjoly, Woog, and Pavan-Langston); the Laboratory of Virology and Chemotherapy, Harvard School of Dental Medicine (Dr Park), Boston.

Arch Ophthalmol. 1984;102(12):1804-1807. doi:10.1001/archopht.1984.01040031462023

• We determined the anti-inflammatory prophylactic effect of topical cyclosporine in a rabbit model of herpetic stromal keratitis. In a first study, we established that presensitization of rabbits prior to corneal intrastromal injection of herpes simplex virus produced a severe stromal keratitis beginning on day 7 after the intrastromal challenge. Twenty-four presensitized rabbits were thereafter divided into three groups for topical treatment five times a day: (1) 1% cyclosporine in a vehicle solution, started on day 4 after intrastromal challenge, plus 1% trifluridine started on day 7 after challenge, (2) the vehicle solution for cyclosporine, started on day 4, plus 1% trifluridine started on day 7, and (3) the vehicle solution for cyclosporine alone, started on day 4. The severity of stromal disease was significantly decreased in eyes treated with combined cyclosporine-trifluridine, whereas trifluridine alone had no effect on the stromal disease. Epithelial disease did not seem to be worse in eyes treated with combined cyclosporine-trifluridine; the incidence and duration of positive cultures, however, were increased in this group.