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December 1984

Ethoxzolamide Analogue Gel: A Topical Carbonic Anhydrase Inhibitor

Author Affiliations

From the Department of Ophthalmology, University of California, Davis, at Sacramento (Dr Lewis); and the College of Pharmacy (Drs Schoenwald and Barfknecht and Mr Eller) and the Department of Ophthalmology (Dr Phelps), University of Iowa, Iowa City.

Arch Ophthalmol. 1984;102(12):1821-1824. doi:10.1001/archopht.1984.01040031479027

• An analogue of ethoxzolamide, 6-hydroxyethoxzolamide, was synthesized to enhance corneal permeability yet retain carbonic anhydrase inhibitory activity for use in lowering intraocular pressure. In a 1% suspension, the analogue caused a small but statistically significant unilateral reduction of IOP when applied to one eye of normal rabbits. When formulated in a gel vehicle, 6-hydroxyethoxzolamide caused a more prolonged and larger reduction in IOP in normal and ocular hypertensive rabbits compared with its effect in suspension or with the parent compound.