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January 1985

Angiotensin-Converting Enzyme Activity in Human Aqueous Humor

Author Affiliations

From the Departments of Ophthalmology, University of California, San Diego (Dr Weinreb) and San Francisco (Dr Sandman), the University of Texas Health Science Center, Dallas (Dr Friberg), and the Department of Oral Biology, University of California, San Francisco (Dr Ryder).

Arch Ophthalmol. 1985;103(1):34-36. doi:10.1001/archopht.1985.01050010038013

• We measured aqueous angiotensin-converting enzyme (ACE) activity in 37 patients. Patients with granulomatous uveitis and probable sarcoidosis (based on increased serum ACE activity or characteristic radiologic findings) had a significant increase in aqueous ACE activity compared with normal subjects. Aqueous ACE activity was also significantly elevated in patients with sarcoid who had normal serum ACE activity. We believe that measurement of aqueous ACE activity should be considered in patients with uveitis who have normal serum ACE activity and are suspected of having sarcoidosis.

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