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January 1985

Ceftriaxone: A New Cephalosporin With Aqueous Humor Levels Effective Against Enterobacteriaceae

Author Affiliations

From the Departments of Medicine (Dr Axelrod and Mr Sheikh) and Ophthalmology (Drs Newton, Sarakhun, Lester, Merhige, Peck, and Francomano), St Luke's-Roosevelt Hospital Center, New York City.

Arch Ophthalmol. 1985;103(1):71-72. doi:10.1001/archopht.1985.01050010075024

• One- or two-gram doses of ceftriaxone were administered intravenously to 30 patients before cataract extraction. With the 1-g dose, mean aqueous humor concentrations of 0.93 and 0.88 μg/mL were found at approximately 2 and 12 hours after administration, respectively. With the 2-g dose, a mean level of 2.47 μg/mL was observed at two hours; levels of more than 2 μg/mL were found in two patients 13 hours after administration. Both the 1- and 2-g doses thus produce aqueous humor levels many times higher than the minimum inhibitory concentration of ceftriaxone for 90% of most Enterobacteriaceae, excluding Pseudomonas. Concentrations adequate for Staphylococcus aureus and Staphylococcus epidermidis were not, however, obtained.