• One- or two-gram doses of ceftriaxone were administered intravenously to 30 patients before cataract extraction. With the 1-g dose, mean aqueous humor concentrations of 0.93 and 0.88 μg/mL were found at approximately 2 and 12 hours after administration, respectively. With the 2-g dose, a mean level of 2.47 μg/mL was observed at two hours; levels of more than 2 μg/mL were found in two patients 13 hours after administration. Both the 1- and 2-g doses thus produce aqueous humor levels many times higher than the minimum inhibitory concentration of ceftriaxone for 90% of most Enterobacteriaceae, excluding Pseudomonas. Concentrations adequate for Staphylococcus aureus and Staphylococcus epidermidis were not, however, obtained.
Axelrod JL, Newton JC, Sarakhun C, et al. Ceftriaxone: A New Cephalosporin With Aqueous Humor Levels Effective Against Enterobacteriaceae. Arch Ophthalmol. 1985;103(1):71–72. doi:https://doi.org/10.1001/archopht.1985.01050010075024
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