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February 1985

Gentamicin, Tobramycin, Amikacin, and Netilmicin Levels in Tears Following Intravenous Administration

Author Affiliations

From the Department of Ophthalmology (Drs Woo, Johnson, and Insler), Pharmacology (Dr George), and Medicine (Dr LaCorte), Tulane Medical School, New Orleans.

Arch Ophthalmol. 1985;103(2):216-218. doi:10.1001/archopht.1985.01050020068022

• Peak and trough tear and serum concentrations were determined in 27 human volunteers undergoing intravenous (IV) gentamicin sulfate, tobramycin sulfate, amikacin sulfate, and netilmicin sulfate therapy. Although effective serum concentrations were achieved, tear levels were subtherapeutic. The mean peak tear concentrations were 0.4 μg/mL, 0.5 μg/ mL, 1.7 μg/mL, and 0.3 μg/mL for gentamicin, tobramycin, amikacin, and netilmicin, respectively. These levels did not approach the minimum inhibitory concentrations for Pseudomonas and raise some concern regarding the risk-benefit ratio of IV antibiotics for bacterial keratitis.

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