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February 1985

Lipopolysaccharide Tolerance Inhibits Eye Inflammation: II. Preliminary Studies on the Mechanism

Author Affiliations

From the Department of Pathology, University of California, San Francisco (Dr Howes), and the Kuzell Institute for Arthritis Research, Medical Research Institute of San Francisco at Pacific Presbyterian Medical Center (Dr Rosenbaum).

Arch Ophthalmol. 1985;103(2):261-265. doi:10.1001/archopht.1985.01050020113032

• The effect of endotoxin tolerance on ocular inflammation was studied in rabbits. Compared with a control group, a passive Arthus reaction in tolerant rabbits was characterized by a sharp decline in the expected increase in vascular permeability and slightly reduced leukocyte extravasation. Aqueous humor withdrawal (paracentesis) and intravitreal injection of prostaglandin E2 were also examined in lipopolysaccharide (LPS)-tolerant rabbits; in both circumstances, ocular protein exudation was decreased. These studies suggest that the prostaglandin system is particularly affected in the ocular responses of LPS-tolerant rabbits, and raise the possibility that other phenomena described in LPS tolerance may have a similar basis.

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