—I agree with Dr Lachapelle that the use of a high-pass filter with a cutoff set at 100 cps might have significantly reduced the variability of our data. We chose a 20-cps cutoff in order to reproduce as closely as possible the original protocol described by Simonsen1 in his seminal work on the electroretinogram as a prognostic tool in a diabetic retinopathy. We were concerned that a failure to confirm his findings might otherwise have been attributable to modification of his protocol. At the present time, we are using digital filtering, which allows us to analyze the waveforms at a variety of different cutoff frequencies.While I agree that physiologic considerations would suggest that the OPs be looked at separately (which we have done), the analysis of our data showed that the summed amplitudes were more useful clinically, both as a predictor of retinopathy progression and for
Bresnick GH. Oscillatory Potentials-Reply. Arch Ophthalmol. 1985;103(4):480. doi:10.1001/archopht.1985.01050040022010
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