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May 1985

Histologic and Immunopathologic Findings in Sympathetic Ophthalmia

Arch Ophthalmol. 1985;103(5):625-627. doi:10.1001/archopht.1985.01050050015003

To the Editor.  —I read with great interest the article by Müller-Hermelink et al1 in the September Archives. According to the authors, they are describing the apparent "early" histologic and immunopathologic events in sympathetic ophthalmia. From the reported clinical ocular findings in their patient, it is very difficult to unequivocally argue for or against the diagnosis of sympathetic ophthalmia. However, I would like to emphasize that the classification of the reported pathologic findings in the enucleated eye as "early events" are unfounded.If our surmise concerning the role of the immune system in the pathology of sympathetic ophthalmia is correct, once a clinical diagnosis of uveal involvement in the sympathizing (noninjured) eye is made, the events that take place in the inciting (injured) eye must have reached the "mature" stage of expression. Therefore, "early" events of clinical symptoms of sympathetic phenomena in the sympathizing eye are a sound possibility.

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