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Article
May 1985

Effects of Intravitreal Administration of Steroids on Experimental Subretinal Neovascularization in the Subhuman Primate

Author Affiliations

From the Department of Ophthalmology, University of Southern California School of Medicine (Drs Ishibashi, Miki, and Ryan, and Ms Patterson), and the Estelle Doheny Eye Foundation (Dr Sorgente), Los Angeles.

Arch Ophthalmol. 1985;103(5):708-711. doi:10.1001/archopht.1985.01050050100026
Abstract

• To elucidate the role of inflammation in the occurrence of experimental subretinal neovascularization caused by highintensity laser photocoagulation, we investigated the effects of vitreal infusion of steroids on laser lesions in a primate model. Dexamethasone, with or without triamcinolone, was infused continuously for two weeks through an indwelling cannula system. The animals were followed up clinically for up to eight weeks. The frequency of subretinal neovascularization in the steroid-treated animals was significantly lower than that in a control group of untreated animals. Although steroids have multiple effects, these results suggest that the inflammatory response, possibly macrophage infiltration, may plan an important role in the occurrence of subretinal neovascularization in our experimental model.

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