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August 1985

Comparison of the Optic Nerve Head in High- and Low-Tension Glaucoma

Arch Ophthalmol. 1985;103(8):1145-1149. doi:10.1001/archopht.1985.01050080057020

• The optic nerves of 34 eyes of 34 patients with low-tension glaucoma were compared with those of 41 eyes of 41 patients with high-tension glaucoma. Mean intraocular pressure in the low-tension group was 16.9 ± 0.7 mm Hg (mean ± SEM) compared with 31.7 ± 0.8 mm Hg in the high-tension group. Mean total visual field loss was not significantly different in the two groups, as determined by computerized threshold perimetry (OCTOPUS). The optic disc rim in low-tension eyes was significantly thinner than in high-tension eyes (P =.018); the largest difference occurred inferiorly and infero-temporally (P <.001). The appearance of the optic nerve is useful to distinguish between these two subtypes of glaucoma and may be a more meaningful indicator than intraocular pressure. Our findings support the hypothesis that there are at least two different mechanisms for optic nerve damage in glaucoma.