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September 1985

Effect of Sulindac on the Permeability of the Blood-Retinal Barrier in Early Diabetic Retinopathy

Author Affiliations

From the Department of Ophthalmology, University of Illinois School of Medicine, Chicago (Dr Cunha-Vaz), and the Departments of Ophthalmology (Drs Mota, Leite, and Abreu) and Endocrinology (Dr Ruas), Coimbra (Portugal) University.

Arch Ophthalmol. 1985;103(9):1307-1311. doi:10.1001/archopht.1985.01050090059032

• To study the effect of sulindac on the alteration of the blood-retinal barrier, 24 insulin-dependent diabetic patients with minimal or no retinopathy were randomly assigned to receive either oral sulindac (200 mg twice daily) or a placebo for a period of six months. All patients underwent fundus photography, fluorescein angiography, and vitreous fluorophotometry before treatment and after 1, 3, and 6 months of treatment. Vitreous fluorophotometry data showed that there were fewer alterations of the blood-retinal barrier in the sulindac group compared with the placebo group during the six-month study period.

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