• We describe a technique for experimental vitrectomy in the rabbit eye, in which the lens remains intact and the postoperative intraocular inflammatory response is minimized. In comparison with combined vitrectomy and lensectomy, our technique allows the fundus to remain visible for follow-up from the very first postoperative day; traction retinal detachment does not develop as a late complication. We also describe a simple method for gross identification and estimation of the amount of residual vitreous qel on the retinal surface.