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October 1985

Association of Trifluorothymidine and Débridement in Herpetic Dendritic Keratitis-Reply

Author Affiliations


Arch Ophthalmol. 1985;103(10):1456. doi:10.1001/archopht.1985.01050100024005

In Reply.  —In our article, we recognized that minimal wiping débridement may leave behind corneal epithelial cells subclinically infected with herpes simplex virus. We chose minimal wiping débridement over wide blunt spatula débridement, because the former is performed more frequentlu1-3 and is less traumatic.We also noted that delaying antiviral therapy for one day following débridement and patching may have been a factor in the failure of our study to show a significant difference in the healing time between group B (treated with trifluridine alone) and group C (treated with débridement and trifluridine). We designed our study so that débridement and patching would be performed similarly in group A (treated with débridement) and group C. We chose to patch patients following débridement to improve comfort and to promote healing.Herbort and Matter describe rapid healing in an uncontrolled study of patients with dendritic herpetic keratitis treated with blunt spatula

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