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October 1985

Why Did Fever Therapy Work?

Author Affiliations

Oklahoma City

Arch Ophthalmol. 1985;103(10):1457. doi:10.1001/archopht.1985.01050100025008

To the Editor.  —It was with great interest that I read the two articles regarding lipopolysaccharide tolerance inhibiting ocular inflammation published in the February Archives.1,2 These articles were of particular interest to me, because in my early years of training, the intravenous injection of killed Salmonella typhosa organisms was a common treatment for uveitis. I personally was involved in this means of therapy. The rate of clearing of uveitis produced by multiple mechanisms was cleared in a very high percentage of cases. The reason for our success was never fully explained. The idea that the stress reaction from the febrile response to the typhoid organisms stimulated the adrenal gland to produce more steroids was not a valid explanation for me. One of the reasons for this is that many of the patients we treated had been previously treated with massive doses of steroids, indeed did have adrenal suppression, were

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