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October 1985

Thermoradiotherapy for Intraocular Tumors

Author Affiliations

From the Medical Department, Brookhaven National Laboratory, Upton, NY (Drs Finger, Packer, and Svitra); RCA Laboratories, David Sarnoff Research Center, Princeton, NJ (Mr Paglione); Cornell University Medical College, North Shore University Hospital, Division of Ophthalmology, Manhasset, NY (Dr Packer); Memorial Sloan-Kettering Cancer Center, Departments of Medical Physics and Radiation Oncology, New York (Drs Finger, Anderson, and Kim); and the Manhattan Eye, Ear and Throat Hospital, Departments of Ophthalmology and Pathology, New York (Drs Finger, Packer, and Jackobiec).

Arch Ophthalmol. 1985;103(10):1574-1578. doi:10.1001/archopht.1985.01050100150039

• We have developed and used a thermoradiotherapy (TRT) plaque to treat choroidal melanoma (Greene strain) in rabbits. A dual-therapy scleral plaque delivers localized hyperthermia (4.8-gigahertz microwave) and ionizing radiation (iodine I 125). Transscleral treatment involves placement of a TRT plaque on bare sclera at the base of an intraocular tumor. Therapeutic doses of ionizing and hyperthermic radiation are then simultaneously delivered to the intraocular tumor. Sparing of normal ocular structures outside the treatment area after the combined therapy has been noted on clinical, gross, and histologic examinations. Our study suggests that the TRT plaque described satisfies the requirements for dual-modality treatment of choroidal melanoma.

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