The status of the eye in both healthy and diseased states depends to a great extent on the behavior of its cellular constituents. The behavior of these cells is in a dynamic state determined in part by the intrinsic nature of the individual cell type and in part by a multitude of signals impinging on the cell. There is currently a great effort among biomedical scientists to understand the way in which these external stimuli affect cell behavior. Two important types of signals that affect cellular behavior are those derived from the extracellular matrix surrounding the cell and those derived from other cells within the vicinity of the responding cell. In the latter case, cells send signals to one another that modify their individual and aggregate behavior. Some of these cell-cell interactions are addressed by two pioneer studies published in this issue of the Archives.1,2 These studies begin to
Patz A. A New Look at the Retinal Pigment Epithelium and Its Neighbors. Arch Ophthalmol. 1985;103(12):1794–1795. doi:10.1001/archopht.1985.01050120028014
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