• Twenty-two Japanese patients with glaucomatocyclitic crisis were typed for HLA-A, HLA-B, and HLA-C antigens to detect the immunogenetic factors in this disease. It was shown that HLA-Bw54 was present in nine (41%) of 22 patients, a significant increase even after correcting the P value for the number of antigens studied. The haplotype frequency of HLA-Bw54-Cw1 showed a significant association, and it was not due to linkage disequilibrium in the Japanese. Our results suggest that immunogenetic factors closely associated with the major histocompatibility complex may play an important role in the pathogenesis of glaucomatocyclitic crisis.
Hirose S, Ohno S, Matsuda H. HLA-Bw54 and Glaucomatocyclitic Crisis. Arch Ophthalmol. 1985;103(12):1837–1839. doi:10.1001/archopht.1985.01050120071023
Coronavirus Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.