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January 1986

Betaxolol vs Timolol: A Six-Month Double-blind Comparison

Author Affiliations

From the Houston Eye Associates, Conner Glaucoma Center, University of Texas Health Science Center, Houston (Drs Stewart and Kimbrough), and the Department of Ophthalmology, Alcon Laboratories Inc, Fort Worth, Tex (Mr Ward).

Arch Ophthalmol. 1986;104(1):46-48. doi:10.1001/archopht.1986.01050130056019

• Betaxolol hydrochloride (0.5%) and timolol maleate (0.5%) were compared in a six-month randomized, double-blind study involving 29 patients with glaucoma. The two drugs were comparable with regard to efficacy in lowering intraocular pressure. Betaxolol effected an average reduction of 7.6 mm Hg (26%); timolol, 8.4 mm Hg (29%). No patient required adjunctive medications during this study. Ocular side effects were mild and similar for both treatments. Neither drug affected corneal sensitivity, visual acuity, basal tear production, or pupil size. Since betaxolol has been shown to have little effect on the cardiopulmonary system, it should be strongly considered for the treatment of glaucoma.

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