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February 1986

Antibacterial Effect of Donor Corneas Stored in Gentamicin-Enriched McCarey-Kaufman Medium

Author Affiliations

From the Lions Eye Research Laboratories, Louisiana State University (LSU) Eye Center, LSU Medical Center, New Orleans. Dr Yau is now with Mackay Memorial Hospital, Taipai, Taiwan.

Arch Ophthalmol. 1986;104(2):263-265. doi:10.1001/archopht.1986.01050140121032

• Penetrating keratoplasty was performed on five pairs of rabbit eyes; one eye of each animal received a donor cornea stored in McCarey-Kaufman (M-K) medium containing gentamicin, and the contralateral eye received a donor cornea stored in M-K medium without gentamicin. At the end of surgery, dilutions of Pseudomonas aeruginosa were introduced into the anterior chamber of both eyes. The eyes receiving gentamicin-enriched corneas showed mild to moderate infection; the contralateral eyes showed significantly more severe infection. The results indicated that donor corneas stored in gentamicin-enriched M-K medium inhibit the growth of bacteria acquired at the time of surgery and thus may improve the safety of such transplantation procedures.

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