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April 1986

Optic Neuropathy in Systemic Lupus Erythematosus

Author Affiliations

From the Department of Ophthalmology, The Wilmer Ophthalmological Institute, Baltimore (Drs Jabs, Miller, and Johnson); the Department of Medicine, Division of Rheumatology, The Johns Hopkins University School of Medicine, Baltimore (Drs Jabs and Stevens); and the Department of Ophthalmology, University of Virginia School of Medicine, Charlottesville (Dr Newman).

Arch Ophthalmol. 1986;104(4):564-568. doi:10.1001/archopht.1986.01050160120026

• We report data from seven cases of optic neuropathy in systemic lupus erythematosus. The visual outcome varied, but improvement occasionally occurred following treatment with corticosteroids. The clinical picture was variable and could present as acute retrobulbar optic neuritis, ischemic optic neuropathy, or slowly progressive visual loss. Visual evoked response testing revealed increased latency in two patients and loss of amplitude in two others; a fifth patient had both findings in the involved eye. Despite the variable presentation, the probable pathogenesis in all cases is vaso-occlusive disease in small vessels of the optic nerves.

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