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May 1986

Subfoveal Choroidal Neovascular Membranes in Age-Related Macular Degeneration: Visual Prognosis in Eyes With Relatively Good Initial Visual Acuity

Author Affiliations

From the Retinal Vascular Center of the Wilmer Institute, The Johns Hopkins Medical Institutions, Baltimore.

Arch Ophthalmol. 1986;104(5):702-705. doi:10.1001/archopht.1986.01050170092029

• We determined the visual prognosis of 94 eyes in 92 patients having (1) agerelated macular degeneration, (2) a discrete choroidal neovascular membrane directly under the center of the foveal avascular zone (subfoveal), and (3) an initial visual acuity of 20/100 or better. Of the patients who were reexamined 24 months following their initial presentation, 77% had lost at least four lines of vision and 64% had lost at least six lines. Estimation of visual loss using a conservative assessment procedure showed four-line visual loss in 65% of the patients and six-line loss in 50%. In general, the better the visual acuity at the initial examination, the more likely the patient was to have a smaller choroidal neovascular membrane. These results suggest that it may be reasonable to consider a randomized clinical trial of laser photocoagulation for this group of patients with a relatively poor visual prognosis.

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