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May 1986

Leukotrienes in the Aqueous Humor of Patients With Uveitis

Author Affiliations

From the Francis I. Proctor Foundation and the Department of Ophthalmology (Drs Parker and Friedlaender) and the Howard Hughes Medical Institute and the Division of Allergy and Immunology of the Department of Medicine (Dr Goetzl), University of California, San Francisco. Dr Parker is now with the University of Washington, Seattle.

Arch Ophthalmol. 1986;104(5):722-724. doi:10.1001/archopht.1986.01050170112033

• Utilizing chromatographic and radioimmunoassay techniques, we measured the concentration of leukotriene (LT) B4 and LTC4/D4/E4 in the aqueous humor of 14 patients with uveitis and seven patients undergoing penetrating keratoplasty or routine cataract extraction. Leukotriene B4 was detected in 11 of 14 patients with uveitis (mean, 0.96 pmole/ mL), and LTC4/D4/E4 was found in 12 of 14 patients with uveitis (mean, 2.0 pmole/mL). In the control group, LTB4 was detected in six of seven patients (mean, 0.57 pmole/mL), and LTC4/D4/E4 was found in six of seven patients (mean, 1.9 pmole/mL). Leukotriene levels did not correlate with clinically assessed aqueous cell and flare. Mean levels of LT in patients with uveitis receiving corticosteroids were nearly double those found in non-steroid-treated patients. Despite apparent differences in LT levels, none of the above differences reached statistical significance.

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