— We appreciate the comments by Drs Finkelstein and Kimble since they deal with important methodologic issues we addressed on conducting the study analysis.The measures for determining hypertension are described in the text. The proportions for cases and controls defined as hypertensive using the three criteria were similar, and thus could not exert a possible bias (90% in both cases and controls were diagnosed on the basis of past history). In no patient was a new diagnosis of hypertension made after the diagnosis of the retinal occlusive event, thus excluding the probability of expectation bias for this condition.As stated, there was no significant difference by age between cases and controls. Both mean age as well as distribution by five- or ten-year age groups (using x2 with Yates correction for these categorical data) were not significantly different between groups. Hence, no further adjustment was made for
Steinmann WC, Brucker AJ, Johnston RL, Holmes JH. Risk Factors of Branch Retinal Vein Occlusion-Reply. Arch Ophthalmol. 1986;104(6):795. doi:10.1001/archopht.1986.01050180025009
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