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August 1986

Low-Dose Colchicine Inhibits Astrocyte, Fibroblast, and Retinal Pigment Epithelial Cell Migration and Proliferation

Author Affiliations

From the Center for Vitreoretinal Research, Wilmer Ophthalmological Institute, The Johns Hopkins Hospital, Baltimore.

Arch Ophthalmol. 1986;104(8):1223-1225. doi:10.1001/archopht.1986.01050200129066

• We studied the effect of low-dose colchicine on cell proliferation and migration. Colchicine at doses well below the level of ocular toxicity was found to be a potent inhibitor of astrocyte, fibroblast, and retinal pigment epithelial (RPE) cell proliferation and migration. A colchicine concentration of 1.3 × 10−8 mol/L, 10−8 mol/L, and 1.7 × 10−8 mol/L showed a 50% inhibition of proliferation for RPE, astrocytes, and fibroblasts, respectively. At 10−7 mol/L, colchicine inhibited 44%, 46%, and 93% of RPE, astrocyte, and fibroblast migration, respectively. Lowdose colchicine appears to be an effective inhibitor of RPE, astrocyte, and fibroblast migration and proliferation in vitro.

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