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November 1986

Optic Nerve Hypoplasia in Infants of Diabetic Mothers

Arch Ophthalmol. 1986;104(11):1587. doi:10.1001/archopht.1986.01050230025014

To the Editor.  —In 1977 one of us (R.A.P.) described 17 children born to severely diabetic mothers who exhibited optic nerve hypoplasia with good visual acuity but visual field defects.1 Two of these patients and the otherwise unaffected sibling of a third had microcornea. A variety of other malformations have been identified as well, including vertebral, limb, cardiac, facial, central nervous system, and renal anomalies.2 Because the prevalence of optic nerve hypoplasia in infants of diabetic mothers is unknown, eye examinations were performed in a group of infants born to mothers who had entered the Diabetes in Early Pregnancy Study.3 From 98 women entered into the study from March 1984 through June 1985, permission was obtained to examine the eyes of 43 infants. The examiner was unaware of the diabetic status of the mother.Of these infants, 28 were born to diabetic mothers and 15 were born

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