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November 1986

Pharmacologic Modification of Subretinal Fluid Absorption in the Rabbit Eye

Author Affiliations

From the Division of Ophthalmology, Stanford (Calif) University Medical Center; and the Veterans Administration Medical Center, Palo Alto, Calif. Dr Negi is now with Kyoto University, Kyoto, Japan.

Arch Ophthalmol. 1986;104(11):1674-1677. doi:10.1001/archopht.1986.01050230112043

• We studied in the rabbit the effects of pharmacologic agents on the absorption of Hanks' solution from the subretinal space of experimental nonrhegmatogenous detachments. Intravenous acetazolamide had no effect at a clinical dose (15 mg/kg) but increased the rate of fluid absorption significantly at high doses (50 mg/kg). Acetazolamide causes systemic pH to fall, while Pco2 and Po2 increase; however, duplicating some of these effects by artificial respiration or breathing 95% O2 plus 5% CO2 did not alter the rate of fluid absorption. Adding cyclic AMP and related agents to the vitreous and subretinal space slowed down fluid absorption by 25%, whereas cyclic GMP analogues increased the rate of absorption by 33%.

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