[Skip to Content]
[Skip to Content Landing]
February 1987

Oral Ketoconazole and Intraocular Amphotericin B for Treatment of Postoperative Candida parapsilosis Endophthalmitis

Author Affiliations

San Francisco

Arch Ophthalmol. 1987;105(2):172-173. doi:10.1001/archopht.1987.01060020026011

To the Editor.  —Postoperative Candida parapsilosis endophthalmitis occurred in a group of patients secondary to the administration of a contaminated lot of intraocular irrigating solution. All patients underwent subsequent therapeutic vitrectomy combined with intravitreal amphotericin B, intravenous intraocular amphotericin B, and oral flucytosine therapy; this group of 15 patients has previously been described.1 We recently treated an additional patient who was exposed to the same lot of contaminated irrigating solution and had a prolonged delay in the presentation of postoperative C parapsilosis endophthalmitis.

Report of a Case.  —An 89-year-old healthy man underwent extracapsular cataract extraction with implantation of an anterior chamber intraocular lens in the right eye in July 1983. Postoperatively, he had a mild persistent iridocyclitis that was treated intermittently with a topical corticosteroid over the ensuing two years.Two months before our examination, the patient noted a mild increase in redness in the eye that had been