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March 1987

Rieger's Anomaly and Glaucoma Associated With Partial Trisomy 16q

Author Affiliations

Columbia, SC

Arch Ophthalmol. 1987;105(3):323. doi:10.1001/archopht.1987.01060030037015

To the Editor.  —Eye abnormalities, excluding congenital glaucoma and goniodysgenesis, are commonly found in syndromes associated with chromosomal aberrations.1 Herein, we present a patient with partial trisomy 16q, as identified through chromosome analysis on lymphocyte culture technique, who also had Rieger's anomaly and congenital glaucoma. To our knowledge, such a case has not been reported previously.

Report of a Case.  —A female infant weighing 2200 g was born to a 29-year-old, gravida 4, para 2 mother. The maternal history is significant in that the infant was conceived after administration of clomiphene therapy. The pregnancy was terminated at 41 weeks' gestation by emergency cesarean section because of fetal distress. The infant was meconium stained and required resuscitation with oxygen to initiate spontaneous respirations.Physical examination at birth disclosed a prominent forehead, closed sutures, and nonpalpable fontanelles. The palpebral fissures were small with an antimongoloid slant, the interpupillary distance was 45