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April 1987

Accurate Gentamicin Solution for Intravitreal Injection

Arch Ophthalmol. 1987;105(4):454. doi:10.1001/archopht.1987.01060040024004

To the Editor.  —We read with interest the recent articles by Drs Conway and Campochiaro1 and McDonald et al2 concerning retinal toxicity from intravitreal gentamicin injection as well as the follow-up letters3,4 in the December 1986 issue of the Archives regarding the accuracy of prepared gentamicin solutions. Noske's3 letter raised concerns that there may be variability in the dilution of gentamicin solutions prior to their intravitreal injection. Some of the final dilutions may then have unsuspectedly high concentrations of antibiotics, which could contribute to retinal damage.For the past several years, we have used Garamycin Intrathecal, produced by the Schering Corp, Kenilworth, NJ, for our intravitreal injections. Each milliliter of this solution contains 2.0 mg of gentamicin solution and 8.5 mg of sodium chloride, resulting in the appropriate concentration (200 μg per 0.1 mL) for intravitreal injection. As such, no dilutions are required from the standard

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