—Mr Alfaro seems to take issue with our selection of patients with "chronic" uveitis and suggests that patients with "acute" uveitis might reveal a larger role for LTs. Unfortunately, nearly all cases of uveitis are chronic or recurrent. When not, one rarely has the opportunity to sample the aqueous humor. Our patient group demonstrated a wide spectrum of uveitis, both in etiology and chronicity.We have some difficulty accepting Mr Alfaro's suggestion that "any conclusions made regarding the role of LTs in human ocular inflammation should be drawn from studies of acute disease processes." This idea ignores the complexity of inflammation, as well as the broader role that has been suggested for LTs in such chronic conditions as psoriasis,1 rheumatoid arthritis,2 ulcerative colitis,3 and bronchial asthma.4
Friedlaender MH, Parker JA. Leukotrienes in Aqueous Humor of Patients With Uveitis-Reply. Arch Ophthalmol. 1987;105(4):457. doi:10.1001/archopht.1987.01060040027012
Monkeypox Resource Center
Customize your JAMA Network experience by selecting one or more topics from the list below.