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June 1987

Ocular Involvement Associated With Chronic Epstein-Barr Virus Disease

Author Affiliations

From the Massachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston (Drs Wong, D'Amico, and Kenyon); Department of Ophthalmology, the New England Medical Center, Tufts University, Boston (Drs Wong and Hedges); the Department of Ophthalmology, University of Michigan, Ann Arbor (Dr Soong); and the Infectious Disease Unit, Medical Services, Massachusetts General Hospital, Boston (Dr Schooley).

Arch Ophthalmol. 1987;105(6):788-792. doi:10.1001/archopht.1987.01060060074036

• Ocular involvement with acute Epstein-Barr virus infection is usually limited to a transient follicular conjunctivitis, although other lesions have been reported. Chronic Epstein-Barr virus infection has recently gained attention, but ocular manifestations have not been emphasized. We describe three patients with chronic infection with prominent ocular involvement. Bilateral uveitis was noted in all patients, ranging from an anterior uveitis that was responsive to steroids to a severe panuveitis with vitritis, cataract, optic disc swelling, and macular edema. In one patient, topical acyclovir ointment resulted in a substantial decrease in the inflammatory reaction when added to systemic acyclovir therapy. Another patient displayed a keratitis that resolved with topical steroid therapy. Cataract and vitreous surgery were also beneficial in the management of these patients.