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July 1987

Coronary Artery Disease as a Contraindication to the Administration of Aminocaproic Acid

Arch Ophthalmol. 1987;105(7):895. doi:10.1001/archopht.1987.01060070031013

To the Editor.  —Aminocaproic acid is an antifibrinolytic drug that is effective in preventing recurrent bleeding in patients with hyphema.1 Pregnancy, bleeding disorders, cancer, and liver and renal disease are contraindications to its use. Herein we report a case in which a patient with coronary artery disease was given aminocaproic acid and discuss a relative contraindication to its use.

Report of a Case.  —An 81-year-old monocular woman was admitted to the Intensive Care Unit at the University of Illinois Hospital for neurosurgical observation following blunt head trauma. The patient was confused and had a hyphema. A computed tomographic scan of the head was normal except for a dislocated lens in the affected eye. The patient's medical history was significant for angina, two myocardial infarctions, cerebrovascular disease, hypertension, and diabetes mellitus. She was being treated with isosorbide dinitrate, hydrochlorothiazide, tolazamide, captopril, and diltiazem hydrochloride. In addition to her preadmission medications,

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